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What is Trestolone Acetate?
Testosterone and its esters are widely used for androgen replacement therapy. Testosterone undergoes 5 alpha-reduction to dihydrotestosterone (DHT) in the prostate and other tissues leading to potentially undesirable consequences in adult males.
Trestolone or 7 alpha-methyl-19-nortestosterone is a synthetic androgen that is ten times as potent as testosterone. Trestolone Acetate is not 5-alpha reduced to DHT. It inhibits gonadotrophin release, suppresses testosterone and sperm production. Yet,Trestolone Acetate provides adequate replacement therapy for most androgen-dependant functions. Trestolone Acetate has a faster metabolic clearance rate than testosterone and, in contrast to testosterone, Trestolone Acetate does not bind to sex hormone binding globulin (SHBG). Trestolone Acetate remains capable of aromatization (to 7-alpha-methyl-estradiol) preserving the benefits estrogen imparts on male physiology.
The Population Council has investigated Trestolone Acetate [specifically Trestolone Acetate (MENT Ac)] for long-term clinical use for contraceptive purposes and hormone replacement therapy. Initial trials suggest it may be an ideal candidate since it is a non-5-alpha reducible androgen and requires lower doses due to its significantly increased potency over testosterone.
Various forms of Trestolone Acetate in human pharmaceutical preparations and devices for contraception and hormone therapy, specifically Trestolone Acetate Ac implant and Trestolone Acetate transdermal gel and patch formulations, are currently under clinical investigation. Trestolone Acetate is absorbed transdermally up to three times the rate of testosterone – 17 methyl testosterone and 17-α methyl testosterone.
Trestolone Acetate, as a transdermal and/or intramuscular preparation, will have application in a wide range of indications beyond androgen replacement therapy and contraception, including, without limitation, primary hypogonadism, testicular failure, ASIH, baldness, sarcopenia, loss of bone mass, muscle wasting and cachexia, BPH, prostate cancer and of course, bodybuilding and sports performance enhancement.