Coluracetam

Coluracetam (code name BCI-540; formerly MKC-231) is a nootropic agent of the racetam family.It was initially developed and tested by the Mitsubishi Tanabe Pharma Corporation for Alzheimer's disease.

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General Details

Coluracetam 135463-81-9 White Crystalline Powder Improving Memory Raw Material

 

Quick Details:

Product Name: Coluracetam
Synonyms: MKC-231 BCI-540
CAS: 135463-81-9
MF: C19H23N3O3
MW: 341.4
Manufacturer:HKYCGC
Assay:99%
Product Categories: Amines;Heterocycles;Intermediates & Fine
Use:Chemicals;Pharmaceuticals;NUPERCAINAL;Other APIs
Packing:Foil bag or as requirments

 

Coluracetam belongs to the wider group of Racetam drugs. It is often touted for its memory boosting effects and for its effects on manic depression and anxiety. Although Coluracetam is mainly associated with these benefits, it has also been reported to boost optic properties (although ongoing studies are needed to identify the exact mechanisms behind this benefit).

 

Coluracetam was shown to markedly improve memory, learning and anxiety.

 

 

Description:

 

Coluracetam (code name BCI-540; formerly MKC-231) is a nootropic agent of the racetam family.It was initially developed and tested by the Mitsubishi Tanabe Pharma Corporation for Alzheimer’s disease. After the drug failed to reach endpoints in its clinical trials it was in-licensed by BrainCells Inc for investigations into major depressive disorder (MDD), which was preceded by being awarded a “Qualifying Therapeutic Discovery Program Grant” by the state of California. Findings from phase IIa clinical trials have suggested that it would be a potential medication for comorbid MDD with generalized anxiety disorder (GAD). BrainCells Inc is currently out-licensing the drug for this purpose. It may also have potential use in prevention and treatment of ischemicretinopathy and retinal and optic nerve injury.

Coluracetam has been shown to reverse the loss of choline acetyltransferase production in the medial septal nucleus of rats exposed to phencyclidine (PCP), and is considered a potential therapeutic drug for schizophrenia.

 

Coluracetam a nootropic agent composed of a Racetam compound synthetically derived from Piracetam. It is also soluble ethanol. It was first developed and tested in Japan by Mitsubishi Tanabe Pharma Corporation for Alzheimer’s disease in 2005. It was then made available to the general public in 2013 and quickly gained recognition for its cognitive effects.

When in action, Coluracetam improves the body’s choline uptake through the high affinity choline uptake (HACU) process; the mechanism for absorbing and converting choline into neurons during the Acetylcholine synthesis process. By facilitating the conversion of large amounts of choline into Acetylcholine, the brain memory, alertness and attention is improved. Coluracetam also affects sections of the brain that are concerned with visual processing, and is therefore touted to improve the sense of sight.

 

Benefits of Coluracetam:

 

According to BrainCells Inc, Coluracetam is a potential treatment for various diseases and disorders that affect the brain and nervous system. Such diseases and disorders that Coluracetam has the potential of treating and preventing include; ischemic retinopathy and optic nerve injuries. The ability of Coluracetam to reverse the loss of choline production makes it a potential drug for treatment of schizophrenia. These refer to the clinical benefits of Coluracetam.

 

Coluracetam also has various other benefits that are not clinical. It is helpful in enhancing cognition, improving the memory and better decision making; it does this by increasing choline uptake and synthesis of Acetylcholine. It is also able to reduce cytotoxicity (a state of being toxic to body cells) of the brain, which is usually caused by an influx of calcium in cultured cortical neurons. This occurs when supply of oxygen to the brain is limited. Coluracetam is also an anti-depressant and can therefore be used in treating various forms of depression. It can be effectively used to deal with stress and hangovers by creating feelings of contentment and peace. This is a motivation boosting nootropic, a distinct feature from the other nootropics. Another unique benefit of Coluracetam is that it is beneficial for eyesight. It improves visual recognition and color vision. Coluracetam has also been found to be effective in the treatment of patients experiencing major depressive disorder and general anxiety disorder making this nootropic supplement an effective anti-depressant.

 

A unique feature of Coluracetam as a nootropic that makes it distinct is that it is the only high affinity choline uptake (HACU) enhancer. This enables it to speed up the flow of Acetylcholine in the brain thereby improving the brain functions of memory, mood, intelligence and learning.

 

The dosage for Coluracetam may not have a medically recommended standard, but a maximum of 200 mg a day is advisable. The dosage also varies depending on the reason for using the supplement. For instance, users taking the supplement to treat major depressive disorder or general anxiety disorder are advised to take 300 mg a day in order to get the maximum benefits.

 

The use of Coluracetam is relatively safe with very few side effects. The common side effect that may be experienced is headaches. This can however be countered by stacking Coluracetam with Centrophenoxine, Alpha GPC, or CDP Choline to reduce such side effects.

 

COA of Coluracetam:

 

Product Name Coluracetam
Analysis Test Specification Result
Description White crystalline powder, odorless Conform
Solubility Easily soluble in water, unsoluble in ethanol Conform
PH 6.0~7.5 6.9
Solution clarity and color Solution should be clear and colorless Conform
Related substances 5’CMP 0.3%
Simple impurity
Total other impurity
0.01%
0.03%
0.10%
Chloride 0.05% Conform
Ammonium 0.05% Conform
Fe 0.01% Conform
Phosphate 0.1% Conform
Loss on drying ≤6.0% 1.3%
Heavy metals 0.002% Conform
Arsenide 0.0001% Conform
Bacterial Endotoxins 0.3EU/mg Conform
Microbial Limit Conform Conform
Assay (on dried basis) ≥99.0% 99.8%

 

Coluracetam DOSING
Since the study subjects were mainly rats, there isn’t any recommended human dosages, but there is a general guideline for conversion.

In rats, the dosage ranged between 1 mg/kg and 10 mg/kg per day. By using allometric scaling, the dose becomes 2.9 mg/kg in humans, so the average dose should not exceed 203.5 mg daily for someone in a typical weight class.

There isn’t very much information to indicate toxicity of Coluracetam, although doses given at the above increments showed no negative side effects. If you haven’t used a nootropic before, you may develop headache after use, which is a common in first time users. By stacking the Coluracetam with Choline, you’ll reduce this risk.

 

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