Letrazole (Femara / Formestane)

emara (letrozole) is a type II (non-steroidal) third generation aromatase inhibitor.

General Details

Letrozole Raw Steroid Powders Femara Dosage Side Effects For Women Breast Cancer

 

Quick details of Letrozole raw steroid powders:

Alias: FEMARA , CGS-20267 , LETROZOL , LETROZOLE , LetrozoleUsp28 , Letrozole99% , CGS-20267, Femara , LETRAZOLE , letrozolex , Lelrozol

CAS No: 112809-51-5

MF: C17H11N5

MW: 285.3

 98% Femara Content Anti Estrogen Steroids , CAS No: 112809-51-5 Melting points 182℃

Purity: 99.2%

Appearance: white powder.

 

Letrozole Femara results COA:

 

Tests

Specifications

Results

Appearance

White or off-white crystaline powder

White

Crystalline powder

Solubility

Soluble in Chloroform;

Soluble in ethanol when heated

Conform

ldentification

(1)Maximum absorption in wavelength of 240 nm

Minimum absorption in wavelength of 215 nm

Conform

Conform

(2)Infrared spectrum should be in accordance the dominant peak of contrast

In accordance with the dominant peak of contrast

Melting points

182℃-184℃

182℃

Related substances

≤0.5%

0.3%

Single impurity

≤0.3%

0.2%

Loss on drying

≤1.0%

0.8%

[Assay]C17H11N5

(On anhydrous basis)

≥98.0%

99.2%

Conclusion

Conforms Specifications of Enterprise Standard.

 

Description:

 

Femara (chemical name: letrozole) is an aromatase inhibitor approved by the U.S. Food and Drug Administration (FDA) to treat:

  • postmenopausal women diagnosed with hormone-receptor-positive, early-stage breast cancer right after surgery (or possibly chemotherapy and radiation) to reduce the risk of the cancer coming back
  • postmenopausal women diagnosed with hormone-receptor-positive early-stage breast cancer who have taken 5 years of tamoxifen to reduce the risk of the cancer coming back
  • postmenopausal women diagnosed with advanced-stage or metastatic hormone-receptor-positive breast cancer 

Femara won’t work on hormone-receptor-negative breast cancer.

 

Femara is a pill taken once a day. Most doctors recommend taking Femara at the same time each day.

In 2011, the FDA gave approval for 11 pharmaceutical companies to make a generic version of Femara, which may go by the chemical name letrozole.

 

You should not take Femara if you are breastfeeding, pregnant, trying to get pregnant, or if there is any chance that you could be pregnant. Femara may cause damage to developing embryos. You should use an effective non-hormonal type of birth control — such as condoms, a diaphragm along with spermicide, or a non-hormonal I.U.D. – while you are taking Femara. Ask your doctor which type of non-hormonal birth control would be best for you, as well as how long you should use this type of birth control after you stop taking Femara.

 

Letrozole femara usage :

1. Femara (letrozole) is a type II (non-steroidal) third generation aromatase inhibitor. Clinically it is used to treat postmenopausal women with either estrogen receptor positive or estrogen receptor unknown breast cancer.

In women with breast cancer, it has been shown to reduce estrogen levels by 98% or more. However, it’s use and benefits are not limited to eliminating estrogen in women.

For pre-contest bodybuilders, Letrozole is almost a necessity to eliminate water retention and achieve the ripped look necessary to compete in today’s bodybuilding world. However, in my experience, it is only necessary to be used for the last 4-6 weeks, to eliminate excess estrogen and water retention. After using

Letrozole I recommend staying away from any estrogen suppression for at least a month to try to normalize the body.

2. Letrozole is used to treat postmenopausal women with hormone receptor positive early breast cancer or who have been treated with tamoxifen (Nolvadex). It also is approved for initial or second-line treatment of postmenopausal women with hormone-sensitive or advanced breast cancer.

 

Application:

Benefits of Femara for women breast cancer

Two large studies have shown the benefits of Femara.

The international BIG 1-98 trial, started in 1998, compared Femara to tamoxifen after surgery in postmenopausal women diagnosed with hormone-receptor-positive, early-stage breast cancer. The results showed that Femara was better than tamoxifen for:

  • increasing the time before the cancer comes back in those who experience recurrence
  • reducing the risk of the cancer spreading to other parts of the body

The MA-17 study, conducted in Canada, looked at whether taking Femara for 5 years AFTER taking tamoxifen for 5 years (for a total of 10 years of hormonal therapy) could lower the risk of the cancer coming back in postmenopausal women diagnosed with hormone-receptor-positive, early-stage breast cancer. The results showed that Femara:

  • reduced the risk of the cancer coming back
  • reduced the risk of the cancer spreading to another part of the body

compared to not taking Femara after 5 years of tamoxifen.

 

Femara Side effects for women breast cancer

Because Femara lowers the amount of estrogen in the body, less estrogen reaches bone cells, which can lead to bone thinning and weakening and a higher-than-average risk of broken bones. This side effect can be very troubling for some women. If you have osteoporosis, your doctor may recommend that you take tamoxifen rather than Femara because of this possible side effect.

Other common side effects of Femara are:

  • bone and joint pain
  • fatigue
  • dizziness
  • drowsiness
  • higher cholesterol
  • hot flashes
  • weight gain
  • nausea
  • vomiting

Some women may have other side effects while taking Femara:

  • swelling of hands, feet, ankles, or lower legs
  • loss of appetite
  • constipation
  • diarrhea
  • difficulty sleeping
  • vaginal bleeding
  • breast pain
  • fever
  • cough
  • dry skin
  • rash

Some side effects may mean that you’re having an allergic reaction to Femara. If you have shortness of breath or chest pain, call your doctor immediately. 

 

How long do I take Femara?

In most cases, you’ll take Femara for 5 years. Doctors may recommend that some women take it for a longer period of time.

 

Femara dosage for breast cancer:

Usual Adult Dose for Breast Cancer:

For use as first-line treatment of postmenopausal women with hormone receptor positive or hormone receptor unknown locally advanced or metastatic breast cancer. Femara is also indicated for the treatment of advanced breast cancer in postmenopausal women with disease progression following antiestrogen therapy: 2.5 mg tablet orally administered once a day without regard to meals.

In patients with advanced disease, Letrozole therapy should continue until tumor progression is evident.

Usual Adult Dose for Breast Cancer – Adjuvant:

For use as extended adjuvant treatment of early breast cancer in postmenopausal women who have received 5 years of adjuvant tamoxifen therapy: 2.5 mg tablet orally administered once a day without regard to meals.

The optimal duration of treatment with Femara is not known. Treatment should be discontinued if there is a tumor relapse.

 

Specification:

  • Alias:Femara , Letrozole ,TROZET
  • Dosage: LETROZOLE TABLETS USP 2.5MG
  • Assay: 98.0-102.0%. USP32
  • CAS: 112809-51-5
  • Usage: Anti estrogen
  • Appearance: White crystalline powder.
  • Active life cycle : 6 hours
  • MW: 285.3
  • MP: 181-183 degrees
  • Half-life : Letrozole 2-4 day

Letrozole Raw Steroid Powders Femara Dosage Side Effects For Women Breast Cancer

 

 

 

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