Letrozole 5

Letrozole is an oral non-steroidal inhibitor for the treatment of hormonally-responsive breast cancer after surgery.

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General Details

Oral Letrazole 5mg/ml Oral Anaboilc Steroids Aromatizing Sex Hormone Steroids Femara Formestane

 

Description:

Alias: FEMARA , CGS-20267 , LETROZOL , LETROZOLE , LetrozoleUsp28 , Letrozole99% , CGS-20267, Femara , LETRAZOLE , letrozolex , Lelrozol

CAS No: 112809-51-5

MF: C17H11N5

MW: 285.3

98% Femara Content Anti Estrogen Steroids , CAS No: 112809-51-5 Melting points 182℃

Purity: 99.2%

Appearance: white powder or light yellow liquid.

 

 

Specification:

COA:

Tests Specifications Results
Appearance White or off-white crystaline powder White

Crystalline powder

Solubility Soluble in Chloroform;

Soluble in ethanol when heated

Conform
ldentification (1)Maximum absorption in wavelength of 240 nm

Minimum absorption in wavelength of 215 nm

Conform

Conform

(2)Infrared spectrum should be in accordance the dominant peak of contrast In accordance with the dominant peak of contrast
Melting points 182℃-184℃ 182℃
Related substances ≤0.5% 0.3%
Single impurity ≤0.3% 0.2%
Loss on drying ≤1.0% 0.8%
[Assay]C17H11N5

(On anhydrous basis)

≥98.0% 99.2%
Conclusion Conforms Specifications of Enterprise Standard.

 

Specifications

 

Letrozole is an oral non-steroidal inhibitor for the treatment of hormonally-responsive breast cancer after surgery.
letrozole prevents the aromatase from producing estrogens by competitive, reversible binding to the heme of its cytochrome p450 unit, the action is specific,and letrozol does not reduce production of mineralo-or corticosteroids.
In cotrast, tamoxifen interferes with estrogen receptor, tamoxifen is also used to treat hormonally-responsive breast cancer. However, letrozol is effective only in post-menopausal women, in whom estrogen is produced predominantly in the main source od estrogen is from the ovaries not the peripheral tissues, and letrozol is ineffective.

 

 

Uses:

 

Letrozole is use for the treatment of local or metastatic breast cancer that is hormone receptor positive or has an unknown receptor status in postmenopausal women.Letrozole has been used for ovarian stimulation by fertility doctors since 2001 because it has fewer side-effects than clomiphene (Clomid) and less chance of multiple gestation. A study presented at the American Society of Reproductive Medicine 2005 Conference suggests that letrozole may increase the risk of birth defects.

 

 

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