Toremifene Citrate

Toremifene citrate is an oral selective estrogen receptor modulator (SERM) which helps oppose the actions of estrogen in the body.

General Details

SERM Toremifene Citrate Fareston Anti Estrogen Steroids For Anticancer Drugs

 

Quick details:

 

  • Toremifene Citrate (Fareston)
  • CAS: 89778-27-8
  • Formula: C26H28ClNO
  • Mol. Mass: 598.09g/mol
  • Melting Point: 158-164 ºC
  • Boiling Point: 535.1 ºC at 760 mmHg
  • Density: 1.045 g/cm3
  • Boiling Point: 535.1 ° C at 760 mmHg
  • Flash Point: 277.4 ° C
  • Solubiltiy: Freely soluble in pyridine and acetic acid, sparingly soluble in methanol, slightly soluble ethanol, very slightly soluble in waterand practically insoluble in diethyl ether
  • Assay: NLT 99.0% (HPLC)
  • Appearance: White or almost white powder
  • Package: 1kg/aluminum foil bag
  • Storage: Preserve in tight containers, protected from humidity, keep in dry and shady place .

COA:

Description White or Almost White Crystalline Powder white powder
Identification A.B. Positive
Assay 97.0~103.0% 99.0%
Specific Rotation +101°~+105° +102.6°
Loss On Drying 1.0%max 0.28%
Organic Volatile Impurities meets the requirement. Conforms
Related Substances meets the requirement. Conforms
Residual Solvents meets the requirement. Conforms
Particle Size 100% ≤ 20 microns Conforms

 

Description:
Toremifene citrate is an oral selective estrogen receptor modulator (SERM) which helps oppose the
actions of estrogen in the body. Licensed in the United States under the brand name Fareston, toremifene
citrate is FDA-approved for use in advanced (metastatic) breast cancer. It is also being evaluated for
prevention of prostate cancer under the brand name Acapodene.
It has already been covered that Toremifene is a SERM, and serves to block Estrogen at various receptor
sites in certain tissues within the body (breast tissue in particular). As a layman explanation, Toremifene
pretends to be a ‘fake’ Estrogen that occupies Estrogen receptors within breast tissue. With these
receptors occupied by Toremifene, real Estrogen cannot perform their jobs there.
Toremifene does not reduce total blood plasma levels of Estrogen. In addition to being antagonistic to
Estrogen receptors in breast tissue, it is also antagonistic to Estrogen at the hypothalamus gland
(this essentially ‘tricks’ the hypothalamus into thinking there is little or no circulating Estrogen levels in the
body, causing it to increase its manufacture of Testosterone so that it can utilize aromatization to restore
these levels.
Toremifene is also agonistic to Estrogen receptors in other tissues in the body (within the liver in particular).
This means that whileToremifene will act as an anti-estrogen in breast tissue and the hypothalamus, it will
act as an Estrogen within the liver. This can have beneficial impacts especially during an anabolic steroid
cycle, such as improving and shifting cholesterol levels into a more favorable range.

 

Dosage:

 

You could start 100-120mgs per day and then lower to 40-60mgs per day for 4-6 weeks.

About SERMS and Gyno Killer :

 

>When a bodybuilder uses anabolic steroids, their LH and FSH drop to near 0. As their pituitary glands will go dormant, they will cease producing testosterone. This is called ‘suppression’ or ‘shutdown’. This will occur with any anabolic steroid cycle and is completely normal.

 

>After their cycle is complete and the steroid esters start to clear the system, a post cycle therapy (PCT) is done to help get the pituitary glands running again. SERM’s work by blocking estrogen going into the pituitary glands, which cause a rise in LH and testosterone levels, temporarily. This helps give a boost after cycle, and it helps maintain gains.

 

>Another benefit to this drug is its gyno fighting abilities. When scientists developed fareston, they noticed it caused 60% of breast cancer cell cultures to exhibit apoptosis, or “programmed death.” Therefore, in theory, someone with gynecomastia would have the same type of result. Not only will it kill existing gyno, but it prevents the cells from progressing.

 

>Fareston has not been used much in the bodybuilding world because it is so new, but there is another reason rarely discussed. There is some evidence that it can hurt free testosterone levels.

Applications :

 

>Toremifene citrate is an oral selective estrogen receptor modulator (SERM) which helps oppose the actions of estrogen in the body. Licensed in the United States under the brand name Fareston, toremifene citrate is FDA-approved for use in advanced (metastatic)breast cancer.>It is also being evaluated for prevention of prostate cancer under the brand name Acapodene.

 

Used for Metastatic breast cancer in postmenopausal women.
PO 60 mg once daily with or without food. Treatment is generally continued until disease progression is observed.

 

 

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