Lidocaine
The efficacy profile of lidocaine as a local anesthetic is characterized by a rapid onset of action and intermediate duration of efficacy. Therefore, lidocaine is suitable for infiltration, block, and surface anesthesia.
Safety Lidocaine Base Local Anesthetic Drugs For Pain Killer APIs 137-58-6
Details:
Lidocaine Base
Lidocaine Base Product Name:Lidocaine Base
Lidocaine Base Synonyms:2-(Diethylamino)-2′,6′-acetoxylidide;2-(diethylamino)-2’,6’-acetoxylidide;2-(diethylamino)-n-(2,6-dimethylphenyl)-acetamid;2′,6′-Acetoxylidide, 2-(diethylamino)-;6’-acetoxylidide,2-(diethylamino)-2;Acetamide, 2-(diethylamino)-N-(2,6-dimethylphenyl)-;Acetamide,2-(diethylamino)-N-(2,6-dimethylphenyl)-;a-Diethylamino-2,6-acetoxylidide
Lidocaine Base CAS:137-58-6
Lidocaine Base MF:C14H22N2O
Lidocaine Base MW:234.34
Lidocaine Base EINECS:205-302-8
Lidocaine Base mp:66-69°C
Lidocaine Base storage temp.:Store at RT
Lidocaine Base solubility:ethanol: 4 mg/mL
Lidocaine Base form:powder
Lidocaine Base Water Solubility:practically insoluble
Lidocaine Base Usage:Lidocaine (Alphacaine)is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM. [1] Histamine is responsible for many features of allergic reactions.
Lidocaine (Alphacaine)is a second-generation antihistamine agent closely st
Biological Activity:Anasthetic and class Ib antiarrhythmic agent.Blocks voltage-gated sodium channels in the inactivated state.
COA:
| Test Items | Standard | Result | |
| Appearance | White or almost white crystalline powder | White crystalline powder | |
| Identification | (1) | Infrared absorption spectrum of the substance is
same as that of Lidocaine Intermediate CRS |
Complies with the requirement |
| (2) | Melting point: 66℃～70℃ | 66℃～68.5℃ | |
| (3) | Complies with the requirement | Complies with the requirement | |
| Related substance | Complies with the requirement | Complies with the requirement | |
| Chlorides | ≤35ppm | ＜35ppm | |
| Sulphates | ≤0.1% | ＜0.1% | |
| Water | ≤1.0% | 0.27% | |
| Sulphated ash | ≤0.1% | 0.01% | |
| Assay | 99.0%～101.0%
(anhydrous substance, C14H22N2O) |
99.41% | |
Applications:
1. The efficacy profile of lidocaine as a local anesthetic is characterized by a rapid onset of action and intermediate duration of efficacy. Therefore, lidocaine is suitable for infiltration, block, and surface anesthesia. Longer-acting substances such asbupivacaine are sometimes given preference for subdural and epidural anesthesias; lidocaine, though, has the advantage of a rapid onset of action. Epinephrine (adrenaline) vasoconstricts arteries, reducing bleeding and also delays the resorption of lidocaine, almost doubling the duration of anaesthesia. For surface anesthesia, several available formulations can be used e.g. for endoscopies, before intubations, etc. Buffering the pH of lidocaine makes local freezing less painful.Lidocaine drops can be used on the eyes for short ophthalmic procedures.
2. Topical lidocaine has been shown in some patients to relieve the pain of postherpetic neuralgia (a complication of shingles), though not enough study evidence exists to recommend it as a first-line treatment.ntravenous lidocaine also has uses as a temporary fix for tinnitus. Although not completely curing the disorder, it has been shown to reduce the effects by around two-thirds.
3. Lidocaine is also the most important class-1b antiarrhythmic drug; it is used intravenously for the treatment of ventricular arrhythmias (for acute myocardial infarction, digoxin poisoning, cardioversion, or cardiac catheterization) if amiodarone is not available or contraindicated. Lidocaine should be given for this indication after defibrillation, CPR, and vasopressors have been initiated. A routine prophylactic administration is no longer recommended for acute cardiac infarction; the overall benefit of this measure is not convincing.
4. Inhaled lidocaine can be used as an antitussive (cough suppressor) acting peripherally to reduce the
cough reflex. This application can be implemented as a safety and comfort measure for patients who have
to be intubated, as it reduces the incidence of coughing and any tracheal damage it might cause when
emerging from anesthesia.
5. Lidocaine, along with ethanol, ammonia, and acetic acid, has also been proven to be effective in
treating jellyfish stings, both numbing the affected area and preventing further nematocyst discharge.
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