Toremifene Citrate
Toremifene citrate is an oral selective estrogen receptor modulator (SERM) which helps oppose the actions of estrogen in the body.
SERM Toremifene Citrate Fareston Anti Estrogen Steroids For Anticancer Drugs
Quick details:
- Toremifene Citrate (Fareston)
- CAS: 89778-27-8
- Formula: C26H28ClNO
- Mol. Mass: 598.09g/mol
- Melting Point: 158-164 ºC
- Boiling Point: 535.1 ºC at 760 mmHg
- Density: 1.045 g/cm3
- Boiling Point: 535.1 ° C at 760 mmHg
- Flash Point: 277.4 ° C
- Solubiltiy: Freely soluble in pyridine and acetic acid, sparingly soluble in methanol, slightly soluble ethanol, very slightly soluble in waterand practically insoluble in diethyl ether
- Assay: NLT 99.0% (HPLC)
- Appearance: White or almost white powder
- Package: 1kg/aluminum foil bag
- Storage: Preserve in tight containers, protected from humidity, keep in dry and shady place .
COA:
| Description | White or Almost White Crystalline Powder | white powder |
| Identification | A.B. | Positive |
| Assay | 97.0~103.0% | 99.0% |
| Specific Rotation | +101°~+105° | +102.6° |
| Loss On Drying | 1.0%max | 0.28% |
| Organic Volatile Impurities | meets the requirement. | Conforms |
| Related Substances | meets the requirement. | Conforms |
| Residual Solvents | meets the requirement. | Conforms |
| Particle Size | 100% ≤ 20 microns | Conforms |
Description:
Toremifene citrate is an oral selective estrogen receptor modulator (SERM) which helps oppose the
actions of estrogen in the body. Licensed in the United States under the brand name Fareston, toremifene
citrate is FDA-approved for use in advanced (metastatic) breast cancer. It is also being evaluated for
prevention of prostate cancer under the brand name Acapodene.
It has already been covered that Toremifene is a SERM, and serves to block Estrogen at various receptor
sites in certain tissues within the body (breast tissue in particular). As a layman explanation, Toremifene
pretends to be a ‘fake’ Estrogen that occupies Estrogen receptors within breast tissue. With these
receptors occupied by Toremifene, real Estrogen cannot perform their jobs there.
Toremifene does not reduce total blood plasma levels of Estrogen. In addition to being antagonistic to
Estrogen receptors in breast tissue, it is also antagonistic to Estrogen at the hypothalamus gland
(this essentially ‘tricks’ the hypothalamus into thinking there is little or no circulating Estrogen levels in the
body, causing it to increase its manufacture of Testosterone so that it can utilize aromatization to restore
these levels.
Toremifene is also agonistic to Estrogen receptors in other tissues in the body (within the liver in particular).
This means that whileToremifene will act as an anti-estrogen in breast tissue and the hypothalamus, it will
act as an Estrogen within the liver. This can have beneficial impacts especially during an anabolic steroid
cycle, such as improving and shifting cholesterol levels into a more favorable range.
Dosage:
| You could start 100-120mgs per day and then lower to 40-60mgs per day for 4-6 weeks. |
About SERMS and Gyno Killer :
| >When a bodybuilder uses anabolic steroids, their LH and FSH drop to near 0. As their pituitary glands will go dormant, they will cease producing testosterone. This is called ‘suppression’ or ‘shutdown’. This will occur with any anabolic steroid cycle and is completely normal.
>After their cycle is complete and the steroid esters start to clear the system, a post cycle therapy (PCT) is done to help get the pituitary glands running again. SERM’s work by blocking estrogen going into the pituitary glands, which cause a rise in LH and testosterone levels, temporarily. This helps give a boost after cycle, and it helps maintain gains.
>Another benefit to this drug is its gyno fighting abilities. When scientists developed fareston, they noticed it caused 60% of breast cancer cell cultures to exhibit apoptosis, or “programmed death.” Therefore, in theory, someone with gynecomastia would have the same type of result. Not only will it kill existing gyno, but it prevents the cells from progressing.
>Fareston has not been used much in the bodybuilding world because it is so new, but there is another reason rarely discussed. There is some evidence that it can hurt free testosterone levels. |
Applications :
| >Toremifene citrate is an oral selective estrogen receptor modulator (SERM) which helps oppose the actions of estrogen in the body. Licensed in the United States under the brand name Fareston, toremifene citrate is FDA-approved for use in advanced (metastatic)breast cancer.>It is also being evaluated for prevention of prostate cancer under the brand name Acapodene. |
| Used for Metastatic breast cancer in postmenopausal women. PO 60 mg once daily with or without food. Treatment is generally continued until disease progression is observed. |
Contact Now
Contact Now
Testolactone
Testolactone is a synthetic antineoplastic agent that is structurally distinct from the androgen steroid nucleus in possessing a six-membered lactone ring in place of the usual five-membered carbocyclic D-ring. Despite some similarity to testosterone, testolactone has no in vivo androgenic effect.
Toremifene Citrate
Toremifene citrate is an oral selective estrogen receptor modulator (SERM) which helps oppose the actions of estrogen in the body.
Raloxifene Hydrochloride
Raloxifene is used to prevent and treat osteoporosis (condition in which the bones become thin and weak and break easily) in women who have undergone menopause (change of life; end of menstrual periods).
DL-Aminoglutethimide
Aminoglutethimide is an adrenal steroid inhibitor. It works by blocking the production of a variety of hormones, including glucocorticoids, mineralocorticoids, estrogens, and androgens and is clinically used in the Treating Cushing syndrome and metastatic breast cancer. Aminoglutethimide is also used by body builders.
Formestane
Formestane is a synthetic steroidal substance with antineoplastic activity. Formestane binds irreversibly to and inhibits the enzyme aromatase, thereby blocking the conversion of cholesterol to pregnenolone and the peripheral aromatization of androgenic precursors into estrogens.
Mesterolone
Mesterolone is an orally applicable androgen, and DHT derivative,is sold under the brand proviron, In the late 70's and early 80'sMestero lone was used with some success in controlled studies ofmen suffering from various forms of depression.
Anastrozole (Arimidex)
Anastrozole is also called Arimidex. It is a type of hormone therapy called an aromatase inhibitor. Anastrozoles treats breast cancer in women who have had their menopause.
Exemestane (Aromasin)
Exemestane is indicated for the adjuvant treatment of postmenopausal women with estrogen-receptor positive early breast cancer who have received two to three years of tamoxifen and are switched to it for completion of a total of five consecutive years of adjuvant hormonal therapy.
Clomiphene Citrate (Clomid)
Clomifene or clomiphene (trademarked as Androxal, Clomid and Omifin, citrate salt Serophene) is a selective estrogen receptor modulator (SERM) that has become the most widely prescribed drug for ovulation induction to reverse anovulation or oligoovulation.
Tamoxifen Citrate (Nolvadex)
Nolvadex (tamoxifen citrate) is very comparable to Clomid, behaves in the same manner in all tissues, and is a mixed estrogen agonist/antagonist of the same type as Clomid.