Tablet is an solid dosage form which consist of one or more active ingredient with excipients.
Excipients are very important part of the tablet formulation,they are pharmacologically inactive
substances included in the formulation which is used as a carrier of active ingredient.Here are
examples of the ready mix tablet binder with excipients premixed formula and percentage of
each item:
1) A simple and cost effective Pre-Mixed Binder Formula.
This formula contains 2 basic but very effective excipients – Microcrystalline Cellulose USP and
Magnesium Stearate NF. Microcrystalline Cellulose has a very high binding capability and creates
tablets that are extremely hard, stable, yet disintegrate rapidly. Magnesium Stearate is a popular
lubricant because it also acts as a glidant and anti-adherent.
Contains:
Microcrystalline Cellulose USP (98.4%) – binder.
Magnesium Stearate NF (1.6%) – lubricant.
(Note:MCC USP102 has larger particles which are more round and dense. It is not as fluffy and
light as MCC USP101, therefore MCC USP102 has better flow properties than MCC USP101.)
2) A premium, top of the line, pre-mixed excipient formula.
It is mixed with a high performance tablet lubricant which is not sensitive to over-mixing when
active ingredients are added. This powder formula has excellent flow properties and will not stick
to punches. Pressed tablets are shiny and very hard, yet disintegrate very rapidly.
Contains:
Microcrystalline Cellulose USP (87%) – main excipient.
Copovidone USP (5%) – sustained release agent / hardener.
Croscarmellose Sodium NF (3%) – disintegrant.
Precipitated Silica USP (2%) – glidant / anti-adherent.
Sodium Stearyl Fumarate NF (1%) – high performance tablet lubricant.
3) A premium, top of the line, pre-mixed excipient formula.
It is mixed with a high performance tablet lubricant which is not sensitive to over-mixing when
active ingredients are added. This powder formula has excellent flow properties and will not stick
to punches. Pressed tablets are shiny and very hard, yet disintegrate very rapidly.
Contains:
Microcrystalline Cellulose 101 USP (87%) – main binder.
Copovidone USP (5%) – sustained release agent / hardener.
Croscarmellose Sodium NF (3%) – disintegrant.
Silicon Dioxide USP (2%) – glidant / anti-adherent.
Sodium Stearyl Fumarate NF (1%) – high performance tablet lubricant.
FD&C Blue #1 (2%)
4) A premium, top of the line, pre-mixed excipient formula.
It is mixed with a high performance tablet lubricant which is not sensitive to over-mixing when
active ingredients are added. This powder formula has excellent flow properties and will not stick
to punches. Pressed tablets are shiny and very hard, yet disintegrate very rapidly.
Contains:
Microcrystalline Cellulose 101 USP (84%) – main binder.
Copovidone USP (5%) – sustained release agent / hardener.
Croscarmellose Sodium NF (3%) – disintegrant.
Silicon Dioxide USP (2%) – glidant / anti-adherent.
Sodium Stearyl Fumarate NF (1%) – high performance tablet lubricant.
FD&C Blue #2 (5%)
5) A premium, top of the line, pre-mixed excipient formula.
It is mixed with a high performance tablet lubricant which is not sensitive to over-mixing when
active ingredients are added. This powder formula has excellent flow properties and will not stick
to punches. Pressed tablets are shiny and very hard, yet disintegrate very rapidly.
Contains:
Microcrystalline Cellulose USP (84%) – main binder.
Copovidone USP (5%) – sustained release agent / hardener.
Croscarmellose Sodium NF (5%) – disintegrant.
Silicon Dioxide USP (2%) – glidant / anti-adherent.
Sodium Stearyl Fumarate NF (1%) – high performance tablet lubricant.
FD&C Red #40 (3%)
6) A premium, top of the line, pre-mixed excipient formula.
It is mixed with a high performance tablet lubricant which is not sensitive to over-mixing when
active ingredients are added. This powder formula has excellent flow properties and will not stick
to punches. Pressed tablets are shiny and very hard, yet disintegrate very rapidly.
Contains:
Microcrystalline Cellulose USP (84%) – main binder.
Copovidone USP (5%) – sustained release agent / hardener.
Croscarmellose Sodium NF (3%) – disintegrant.
Silicon Dioxide USP (2%) – glidant / anti-adherent.
Sodium Stearyl Fumarate NF (1%) – high performance tablet lubricant.
FD&C Yellow #5 (5%)
7) A premium, top of the line pre-mixed excipient formula containing Microcrystalline Cellulose.
It is mixed with a high performance tablet lubricant which is not sensitive to over-mixing when
active ingredients are added. This powder formula has excellent flow properties and will not
stick to punches. Pressed tablets are shiny and very hard, yet disintegrate very rapidly.
Contains:
Microcrystalline Cellulose 102 USP (89%) – main excipient.
Copovidone USP (5%) – sustained release agent / hardener.
Croscarmellose Sodium NF (3%) – disintegrant.
Precipitated Silica USP (2%) – glidant / anti-adherent.
Sodium Stearyl Fumarate NF (1%) – high performance tablet lubricant.
