10Liter GBL / Gamma Butyrolactone CAS: 96-48-0

GBL is a lactone. It is hydrolyzed under basic conditions, for example in a sodium hydroxide solution into sodium gamma - hydroxybutyrate, the sodium salt of gamma - hydroxybutyric acid. Under acidic conditions it forms an equilibrium mixture of both compounds. These compounds then may go on to form a polymer. When treated with a non - nucleophilic base, like lithium diisopropylamide, GBL can become an alpha - carbon nucleophile. The related compound caprolactone can be used to make a polyester in this manner.

Category:
General Details
Gamma Butyrolactone Quick Detail:
Product name: GBL Gamma Butyrolactone
No. 96-48-0
Chemical Name: gamma-Butyrolactone
Synonyms: GBL;BLO;6480;BLON;c-1070;GBL-EL;gamma-BL;CadionGr;Butanolid;FEMA 3291
Molecular Formula: C4H6O2
Formula Weight: 86.09
Chemical Properties:colourless oily liquid
General Description:Clear colorless oily liquid with a pleasant odor.
Air & Water Reactions:Hygroscopic,Soluble in water.
Packing: According to the request.
Certification:SGS;ISO9000
Usage :pharmaceutical raw materials, the hormone
Assay: 99%
Payment Terms: T/T, Western Union, MoneyGram
Shipping way: EMS, HKEMS, DHL, TNT, Fedex, UPS… (you can choose the fastest and your favourite)

 

Description

GBL is a lactone. It is hydrolyzed under basic conditions, for example in a sodium hydroxide solution into sodium gamma – hydroxybutyrate, the sodium salt of gamma – hydroxybutyric acid. Under acidic conditions it forms an equilibrium mixture of both compounds. These compounds then may go on to form a polymer. When treated with a non – nucleophilic base, like lithium diisopropylamide, GBL can become an alpha – carbon nucleophile. The related compound caprolactone can be used to make a polyester in this manner.

GBL is not active in its own right; its mechanism of action stems from its identity as a prodrug of GHB. The hypnotic effect of GHB is enhanced by combination with alcohol. A 2003 rat study showed that GBL in combination with ethanol showed a potentiated hypnotic effect, as the sleep-timing measure was longer than both of the individual components combined

GBL is rapidly converted into GHB by paraoxonase ( lactonase ) enzymes, found in the blood. Animals which lack these enzymes exhibit no effect from GBL. GBL is more lipophilic ( fat soluble ) than GHB, and so is absorbed faster and has higher bioavailability. Because of these pharmacokinetic differences, GBL tends to be more potent and faster – acting than GHB, but has a shorter duration; whereas the related compound 1,4- butanediol ( 1,4- B ) tends to be slightly less potent, slower to take effect but longer – acting than GHB.

Gamma Butyrolactone is an important chemical raw material and intermediate for medicine, and also the intermediate of the synthesize N-methyl pyrrolidone, α -pyrrolidone, polyvinyl pyrrolidone, α -acetyl-γ -butyrolactone, methionine and the butyric acid compounds. This product features a strong solubility, and is a good solvent for polyacrylonitrile, epoxy resin, polyvinyl butyral, polyvinyl chloride and its copolymers, and cellulose polymers. In medical industry, it is mainly used in synthesizing cyclopropylamine, etc

 

 

Contact Now

  • 4 + 5 =
Order Enquiry

Contact Now

  • 5 + 80 =
Comments

Leave a Reply

Your email address will not be published. Required fields are marked *