Dextromethorphan Hydrobromide

DXM is also used recreationally. When exceeding label-specified maximum dosages, dextromethorphan acts as a dissociative hallucinogen. Its mechanism of action is via multiple effects, including actions as a nonselective serotonin reuptake inhibitor and a sigma-1 receptor agonist.

General Details

DXM Dextromethorphan Hydrobromide Weight Loss Steroids Pharma Grade Medicine 99 %

 

Quick details:

 

Dextromethorphan Hydrobromide
Alias:  Romilar ; DXM
CAS No.: 125-69-9
EINECS No.: 204-750-1
MF: C18H26BrNO
MW: 352.31

 

Healthy Weight Loss Powders , Romilar / DXM CAS No. 125-69-9

 

Purity: 98.0%
Appearance: White or kind of white crystalline powder, soluble in water.
Usage: Cough medicine

 

Description:

 

Dextromethorphan (DXM or DM) is an antitussive (cough suppressant) drug. It is one of the active

ingredients in many over-the-counter cold and cough medicines,

including generic labels and store brands, Benylin DM, Mucinex DM, Robitussin, NyQuil, Dimetapp,

Vicks, Coricidin, Delsym, TheraFlu, and others. Dextromethorphan has also found other uses in

medicine, ranging from pain relief to psychological applications. It is sold in syrup, tablet, spray, and

lozenge forms. In its pure form, dextromethorphan occurs as a white powder.

 

DXM is also used recreationally. When exceeding label-specified maximum dosages,

dextromethorphan acts as a dissociative hallucinogen. Its mechanism of action is via multiple effects,

including actions as a nonselective serotonin reuptake inhibitor and a sigma-1 receptor agonist.

DXM and its major metabolite, dextrorphan, also acts as an NMDA receptor antagonist at high doses,

which produces effects similar to, yet distinct from, the dissociative states created by other dissociative

anaesthetics such as ketamine and phencyclidine. As well, the metabolite 3-methoxymorphinan

of dextrorphan (thus a second-level metabolite of DXM) produces local anesthetic effects

in rats with potency above dextrorphan, but below that of DXM.

 

Medical use

 

Generic Dextromethorphan syrup.

The primary use of dextromethorphan is as a cough suppressant, for the temporary relief of cough

caused by minor throat and bronchial irritation (such as commonly accompanies the flu and common

cold), as well as those resulting from inhaled particle irritants.

 

A 2004 study showed that dextromethorphan was no more effective for children than a placebo.Studies

conducted by the American Academy of Pediatrics show that dextromethorphan is not superior to a

placebo in providing nocturnal symptom relief for children with cough and sleep difficulty due to upper

respiratory infections.

 

A combination of dextromethorphan and quinidine, a CYP2D6 inhibitor, has been shown to alleviate

symptoms of easy laughing and crying (pseudobulbar affect) in patients with amyotrophic lateral

sclerosis and multiple sclerosis.Dextromethorphan is also being investigated as a possible treatment for

neuropathic pain and pain associated with fibromyalgia.In 2010, the FDA approved the combination

product dextromethorphan/quinidine (Nuedexta) for the treatment of pseudobulbar affect (PBA).

 

Dextromethorphan has been shown to be effective in treating opioid withdrawal. At doses of 2 mg/kg in

rats all signs of opioid withdrawal were eliminated.

 

Description:

 

DXM is also used recreationally. When exceeding label-specified maximum dosages, dextromethorphan acts as a dissociative hallucinogen. Its mechanism of action is via multiple effects, including actions as a nonselective serotonin reuptake inhibitor and a sigma-1 receptor agonist. The major metabolite of DXM, dextrorphan, also acts as an NMDA receptor antagonist. In high doses this produces effects similar to, yet distinct from, the dissociative states created by other dissociative anaesthetic such as ketamine and phencyclidine. As well, the metabolite 3-methoxymorphinan of dextrorphan (thus a second-level metabolite of DXM) produces local anesthetic effects in rats with potency above dextrorphan, but below that of DXM.

 

Specifications:

Test Items Specification Test Results
Appearance white or almost white crystalline powder, slightly smelly white crystalline powder
Melting point 123~127℃ 123~125℃
Specific Rotation +28°~+30° +29°
Acidity(PH) 5.2~6.5 5.8~6.2
Water 4.0%~5.5% 5.0%
Residue On Ignition Not more than 0.1% Conforms
N.N – dimethylaniline Comply with the standard Conforms
Phenolic Compounds Comply with the standard Conforms
Related Substance Comply with the standard Conforms
Assay Between99.0~102.0% 99.53%
Conclusion This batch is complies with USP 34.

 

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