Tetracaine Hydrochloride

Raw Local Anesthetic Powder Anesthetic Anodyne 136-47-0 Tetracaine Hcl Tetracaine Hydrochloride

 

Quick Detail:

 

Product Name: Tetracaine hydrochloride
Synonyms: L AND OCAIN HYDROCHLORIDE;
CAS: 136-47-0
MF: C15H25ClN2O2
MW: 300.82
EINECS: 205-248-5
Product Categories: Amines;Heterocycles;Intermediates & Fine

Chemicals;Pharmaceuticals;NUPERCAINAL;Other APIs
Packing:Foil bag or as requirments

 

Specification:

 

COA

 

Items	QUALITY STANDARDS	RESULTS
Description	White or almost white crystalline powder	White crystalline powder
Solubility	Matching with the working standard	Complies
Identification	A.By IR, To match with working standard	Complies
	B: To 10ml of solution S add 1ml of ammonium thiocyanate solution R.A white,crystalline precipitate is formed which,after recrystallisation from water R and drying at 80℃ for 2h,melts at about 131℃	Complies
	C. To about 5mg add 0.5ml of fuming nitric acid R .Evaporate to dryness on a water-bath,allow to cool and dissolve the residue in 5ml of acetone R.Add 1ml of 0.1M alcoholic potassium hydroxide.A violet colour develops	Complies
	D. Solution S gives reaction of chlorides.	Complies
PH	4.5～6.5	5.78
Residual Solvents	Conform to standard	Complies
Claruty	Solution should be clear	Complies
Related Substances	Conform to standard	Complies
Heavy metals	≤10ppm	＜10ppm
Loss on drying	≤1.0%	0.87%
Resiue on ignition	≤0.1%	0.05%
Melting range	148℃	147.5℃～150.8℃
Assay(*)	99%～101.0%	100.40%
Conclusion	The Sample Complies With Specification of EP8

 

Description:

 

Tetracaine HCl is synthesized from 4-butylaminobenzoic acid. The ethyl ester is formed through an acid-catalyzed esterification reaction. Base-catalyzed transesterification is achieved by boiling the ethyl ester of 4-butylaminobenzoic acid with excess 2-dimethylaminoethanol in the presence of a small amount of sodium ethoxide.

 

Application:

 

Tetracaine (INN, also known as amethocaine; trade name Pontocaine. Ametop and Dicaine) is a potent local anesthetic of the ester group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia.
In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.
use:Used for mucosal epidermal anesthesia, nerve tissue anesthesia, epidural anesthesia and Subarachnoid space anesthesia.

In the manufacture of pharmaceutical preparation for external use, to relieve the pain of drugs or medication lesions pain.

 

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