Tetracaine

Tetracaine Base Tetracaine Hydrochloride Use Local Anesthetic Drugs

 

Product Details:

 

English name: 2- (Dimethylamino) ethyl 4- (n-butylamino) benzoate
English Name: tetracaine usp; tetracaine free base; Tetracaine Base; amethocaine; Dimethylaminoethylnbutylaminobenzoate; Tetracaine; 2- (dimethylamino) ethyl 4- (butylamino) benzoate
CAS: 94-24-6
EINECS Number: 202-316-6
Formula: C15H24N2O2
MW: 264.3633
Molecular Structure:

 

Density: 1.044g / cm3
Boiling point: 389.4 ° C at 760 mmHg
Flash Point: 189.3 ° C
Vapor Pressure: 2.87E-06mmHg at 25 ° C

Assay:99%

Appearance:White crystalline powder

 

Description:

 

Tetracaine is a local anesthetic (numbing medicine). It works by blocking nerve signals in your body.

Tetracaine topical (for the skin) is used to numb different parts of the body before a medical test or procedure.

Tetracaine topical may also be used for purposes not listed in this medication guide.

An overdose of numbing medicine can cause fatal side effects if too much of the medicine is absorbed through your skin and into your blood. This is more likely to occur when using a numbing medicine without the advice of a medical doctor (such as during a cosmetic procedure like laser hair removal). Overdose symptoms may include uneven heartbeats, seizure (convulsions), coma, slowed breathing, or respiratory failure (breathing stops).

Your body may absorb more of this medicine if you use too much, if you apply it over large skin areas, or if you apply heat, bandages, or plastic wrap to treated skin areas. Skin that is cut or irritated may also absorb more topical medication than healthy skin.

Use the smallest amount of this medicine needed to numb the skin or relieve pain.

 

Applications:
 

Tetracaine (INN, also known as amethocaine; trade name Pontocaine. Ametop and Dicaine) is a potent local anesthetic of the ester group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia.

 

In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.

 

Tetracaine is the T in Tac, a mixture of 5 to 12 per cent tetracaine, 5‱ (per myriad), a half per mille (0.5‰), or .05 per cent (1 part in 2000) adrenaline, and 4 or 10 per cent cocaine hydrochloride used in ear, nose & throat surgery and in the emergemcy department where numbing of the surface is needed rapidly, especially when children have been injured in the eye, ear, or other sensitive locations.

 

It is on the World Health Organization’s List of Essential Medicines, a list of the most important medication needed in a basic health system.

 

A systematic review and meta-analysis of randomised controlled trials investigated tetracaine for use in emergency departments, especially for IV cannulation in children, in view of its analgesic and cost-saving properties – however it did not find a statistically significant improvement in first attempt cannulations.

 

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