Coluracetam

Coluracetam 135463-81-9 White Crystalline Powder Improving Memory Raw Material

 

Quick Details:

Product Name: Coluracetam
Synonyms: MKC-231 BCI-540
CAS: 135463-81-9
MF: C19H23N3O3
MW: 341.4
Manufacturer:HKYCGC
Assay:99%
Product Categories: Amines;Heterocycles;Intermediates & Fine
Use:Chemicals;Pharmaceuticals;NUPERCAINAL;Other APIs
Packing:Foil bag or as requirments

 

Coluracetam belongs to the wider group of Racetam drugs. It is often touted for its memory boosting effects and for its effects on manic depression and anxiety. Although Coluracetam is mainly associated with these benefits, it has also been reported to boost optic properties (although ongoing studies are needed to identify the exact mechanisms behind this benefit).

 

Coluracetam was shown to markedly improve memory, learning and anxiety.

 

 

Description:

 

Coluracetam (code name BCI-540; formerly MKC-231) is a nootropic agent of the racetam family.It was initially developed and tested by the Mitsubishi Tanabe Pharma Corporation for Alzheimer’s disease. After the drug failed to reach endpoints in its clinical trials it was in-licensed by BrainCells Inc for investigations into major depressive disorder (MDD), which was preceded by being awarded a “Qualifying Therapeutic Discovery Program Grant” by the state of California. Findings from phase IIa clinical trials have suggested that it would be a potential medication for comorbid MDD with generalized anxiety disorder (GAD). BrainCells Inc is currently out-licensing the drug for this purpose. It may also have potential use in prevention and treatment of ischemicretinopathy and retinal and optic nerve injury.

Coluracetam has been shown to reverse the loss of choline acetyltransferase production in the medial septal nucleus of rats exposed to phencyclidine (PCP), and is considered a potential therapeutic drug for schizophrenia.

 

Coluracetam a nootropic agent composed of a Racetam compound synthetically derived from Piracetam. It is also soluble ethanol. It was first developed and tested in Japan by Mitsubishi Tanabe Pharma Corporation for Alzheimer’s disease in 2005. It was then made available to the general public in 2013 and quickly gained recognition for its cognitive effects.

When in action, Coluracetam improves the body’s choline uptake through the high affinity choline uptake (HACU) process; the mechanism for absorbing and converting choline into neurons during the Acetylcholine synthesis process. By facilitating the conversion of large amounts of choline into Acetylcholine, the brain memory, alertness and attention is improved. Coluracetam also affects sections of the brain that are concerned with visual processing, and is therefore touted to improve the sense of sight.

 

Benefits of Coluracetam:

 

According to BrainCells Inc, Coluracetam is a potential treatment for various diseases and disorders that affect the brain and nervous system. Such diseases and disorders that Coluracetam has the potential of treating and preventing include; ischemic retinopathy and optic nerve injuries. The ability of Coluracetam to reverse the loss of choline production makes it a potential drug for treatment of schizophrenia. These refer to the clinical benefits of Coluracetam.

 

Coluracetam also has various other benefits that are not clinical. It is helpful in enhancing cognition, improving the memory and better decision making; it does this by increasing choline uptake and synthesis of Acetylcholine. It is also able to reduce cytotoxicity (a state of being toxic to body cells) of the brain, which is usually caused by an influx of calcium in cultured cortical neurons. This occurs when supply of oxygen to the brain is limited. Coluracetam is also an anti-depressant and can therefore be used in treating various forms of depression. It can be effectively used to deal with stress and hangovers by creating feelings of contentment and peace. This is a motivation boosting nootropic, a distinct feature from the other nootropics. Another unique benefit of Coluracetam is that it is beneficial for eyesight. It improves visual recognition and color vision. Coluracetam has also been found to be effective in the treatment of patients experiencing major depressive disorder and general anxiety disorder making this nootropic supplement an effective anti-depressant.

 

A unique feature of Coluracetam as a nootropic that makes it distinct is that it is the only high affinity choline uptake (HACU) enhancer. This enables it to speed up the flow of Acetylcholine in the brain thereby improving the brain functions of memory, mood, intelligence and learning.

 

The dosage for Coluracetam may not have a medically recommended standard, but a maximum of 200 mg a day is advisable. The dosage also varies depending on the reason for using the supplement. For instance, users taking the supplement to treat major depressive disorder or general anxiety disorder are advised to take 300 mg a day in order to get the maximum benefits.

 

The use of Coluracetam is relatively safe with very few side effects. The common side effect that may be experienced is headaches. This can however be countered by stacking Coluracetam with Centrophenoxine, Alpha GPC, or CDP Choline to reduce such side effects.

 

COA of Coluracetam:

 

Product Name	Coluracetam
Analysis Test	Specification	Result
Description	White crystalline powder, odorless	Conform
Solubility	Easily soluble in water, unsoluble in ethanol	Conform
PH	6.0~7.5	6.9
Solution clarity and color	Solution should be clear and colorless	Conform
Related substances	5’CMP 0.3% Simple impurity Total other impurity	0.01% 0.03% 0.10%
Chloride	0.05%	Conform
Ammonium	0.05%	Conform
Fe	0.01%	Conform
Phosphate	0.1%	Conform
Loss on drying	≤6.0%	1.3%
Heavy metals	0.002%	Conform
Arsenide	0.0001%	Conform
Bacterial Endotoxins	0.3EU/mg	Conform
Microbial Limit	Conform	Conform
Assay (on dried basis)	≥99.0%	99.8%

 

Coluracetam DOSING
Since the study subjects were mainly rats, there isn’t any recommended human dosages, but there is a general guideline for conversion.

In rats, the dosage ranged between 1 mg/kg and 10 mg/kg per day. By using allometric scaling, the dose becomes 2.9 mg/kg in humans, so the average dose should not exceed 203.5 mg daily for someone in a typical weight class.

There isn’t very much information to indicate toxicity of Coluracetam, although doses given at the above increments showed no negative side effects. If you haven’t used a nootropic before, you may develop headache after use, which is a common in first time users. By stacking the Coluracetam with Choline, you’ll reduce this risk.

 

Related products as below.
Ostarine,MK-2866, Enobosarm
Andarine (S-4)
MK-677, Ibutamoren             
LGD-4033                          
GW-501516                       
AICAR                             
SR9009                          
SR9011                          
RAD-140
Flibanserin                          
Carphedon                         
Coluracetam                       
Sunifiram                          
Adrafinil
Pirfenidone
4-CMC
PV-8                 
Cabergoline

 

Our Service:
1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. Quality can be promised. Hot sell to Worldwide.
3. Payment Terms: T/T,WU,MoneyGram,Paypal Available.
4. Free Sample available at any time.
5. Tracking your order at any time. Inform your order’s further new situation at any time.
6. Package: Professional packing with professional materials.

 

Our advantage:
1. We have experience in exporting steroids, as you know, EU places much emphasis on them, and you must find a experienced partner who will assure you;
2. Quality: Our company is a professional leading factory in China in pharmaceutical area, We had stable customers and exported to Germany, Spain, UK, USA, Australia, Middle East, and any other countries. We can provide good references about our company. As for the quality of the products, we ‘re sure they can satisfy you well enough;
3. Package: Professional packing with professional materials
4. Delivery: We have products in stock, and we will deliver them soon when your PO arrived. Meanwhile we will give you the tracking number in order to make you know the exact location of the products. We will keep track of the product until they arrive you; We choose the best courier service for you, and with the delivery around 5-7 working days.
5. Service: Best Service with after-sales service and consultation

 

 

Our SARMs:

 

Product name	CAS No.
Ostarine,MK-2866, Enobosarm	841205-47-8;1202044-20-9
Andarine (GTX-007,S-4)	401900-40-1
MK-677, Ibutamoren,	159752-10-0
LGD-4033	1165910-22-4
GW-501516(cardarine)	317318-70-0
AICAR	2627-69-2
SR9009	137986-29-9
SR9011	1379686-30-2
RAD-140	118237-47-0
Flibanserin	167933-07-5
Carphedon	77472-70-9
Coluracetam	135463-81-9
Adrafinil	63547-13-7
Pirfenidone	53179-13-8
Pirfenidone	314728-85-3

Why choose us?

 

Professional Manufacture: HKYCGC
is a legit and professional pharmaceutical manufacturer specialized in steroid hormone powders, steroid
injectable liquids, peptides,pharmaceutical raw materials & its intermediate.Our factory is in Nanhu Shouyi
Industrial District, just by the side of the beautiful South Lake in Wuhan. Our company integrates R&D,
producing, operating and marketing into an organic whole. All products are produced under
GMP conditions according to Standard Operation Procedure(SOP),not from little underground labs or black markets, so the quality is guaranteed. We have authority of export and import, and have experience of export for more than 10 years.
Minimum Order: 10-100 grams.our min packing of each powder is 10g or 100g, but some expensive powder can be bought at several grams.
Payment Method: Western Union,Money Gram,T/T.

Professional Delivery: By courier ( EMS, DHL, Fedex, UPS,TNT) is prefered, bulk order can be negotiated.5-7 business days delivery in timely manner. Tracking No. is available ,we can provide you latest tracking of our customers to check validity of delivery if you need.
Discreetly Packing: Safe and professional disguised package can be guaranteed.
Plenty In Stock: Most of powders are in stock.We export over 1000 kilograms of steroid powder per month.
High Delivery Rate: Our goods packing will not contain any hormone information and can be sent out from different areas of china. At present,the goods customs clearance rate we send to United states and Europe is 99%,  As for Canada, Brazil of quite high buckle close rate area, we also have a new way to get through the customs. We also have completely re-send policy to some areas.

 

 

Contact Now