Pirfenidone
Biological Activity: Antifibrotic agent, effective in models of pulmonary and lung fibrosis. Inhibits collagen production and fibroblast proliferation. Regulates cytokine levels following oral administration in vivo . Potent scavenger of free radicals and inhibitor of lipid peroxidation.
53179-13-8 Pharmaceutical Raw Material Antineoplastic Pirfenidone for Nootropics Medicine
Quick Details:
Product Name: Pirfenidone
Alias: S-7701, AMR-69
Synonyms: 5-methyl-1-phenyl-2(1h)-pyridon;amr-69;PIRFENIDONE;5-METHYL-1-PHENYL-1H-PYRIDIN-2-ONE;5-METHYL-1-PHENYL-2(1H)-PYRIDINONE;5-METHYL-1-PHENYL-2-(1H)-PYRIDONE;5-Methyl-N-phenyl-2-1H-pyridone;Pirfenidone also see 5-Methyl-1-Phenyl-2(1H)-Pyridinone
CAS: 53179-13-8
MF: C12H11NO
MW: 185.22
Appearance: A little yellow to white powder
Purity: 99.70%
Shelf life: 3 years
Standard: Enterprise standard
Usage: Pirfenidone has demonstrated activity in multiple fibrotic conditions, including those of the lung, kidney and liver.
Mini order: Only 1g, 10g
Package: Super discreet to ensure 100% pass rate
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Payment: T/T, Bank Transfer, Western Union, Paypal, Money Gram and Bitcoin
Lead time: Within 12 hours upon receipt of payment
Delivery: All Express Modes (EMS, DHL, TNT, FedEx, UPS, etc.)
Shipping time: 3-7 days by express door-to-door
Pirfenidone Quality Test Report(COA):
Pirfenidone Description and Applications:
Biological Activity: Antifibrotic agent, effective in models of pulmonary and lung fibrosis. Inhibits collagen production and fibroblast proliferation. Regulates cytokine levels following oral administration in vivo . Potent scavenger of free radicals and inhibitor of lipid peroxidation.
In vitro, pirfenidone can inhibit the uterine flesh tumour cells and leiomyoma cells proliferation. Pirfenidone can inhibit the TGF – beta – 1 inducing fibroblast collagen formation. Inhibition of PDGF, FGF and TGF – beta – 1 inducing fibroblast proliferation. In hamster model, pirfenidone, taken by mouth, that can the prevention and treatment of pulmonary fibrosis induced by bleomycin. Pirfenidone can prevent the sclerosing peritonitis in rats induced by chemical, can also be keloid grafting for the treatment of nude mice. Pirfenidone 0.01 1 mg/ml can suppress the matrix and dose dependent manner serum stimulate uterine fibroids and leiomyoma cell DNA synthesis, the compound has no cytotoxic effect, has no effect on collagen mRNA level also. Pirfenidone in hamster pulmonary fibrosis model can reduce the disease before the collagen I mRNA level enhancement, reduce the level of the lung hydroxyproline and malondialadehyde and lung preserved ammonia acyl hydroxylase activity.
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