Yohimbine HCL
Yohimbine common brand names are: Erex, Testomar, Yocon, Yohimar, Yohimbe. It is a stimulant with aphrodisiac and mild MAOI effects that primarily acts as an antagonist of α2 receptors. It is sometimes sold as prescription medicine in pure form for the treatment of xerostomia and sexual dysfunction. Yohimbine was explored as a remedy for type 2 diabetes in animal and human models carrying polymorphisms of the α2A-adrenergic receptor gene.
Yohimbine hydrochloride
Synonyms: CORYNINE HYDROCHLORIDE;APHRODINE HYDROCHLORIDE;APHROSOL HYDROCHLORIDE;17-HYDROXYYOHIMBAN-16-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE;17A-HYDROXYYOHIMBAN-16A-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE;YOHIMBE HCL;YOHIMBINE HCL;YOHIMBINE HYDROCHLORIDE
CAS: 65-19-0
MF: C21H27ClN2O3
MW: 390.9
EINECS: 200-600-4
Chemical Properties white to slightly yellow powder
Usage Indole alkaloid with α2-adrenergic blocking activity. Mydriatic. Used in the treatment of neurological disorders.
Usage alpha adrenergic blocker, mydriatic, antidepressant
Usage vasodilator, neuromodulator
Usage a2-adrenergic antagonist, used for erectile dysfunction
Yohimbine hydrochloride Description:
Yohimbine common brand names are: Erex, Testomar, Yocon, Yohimar, Yohimbe. It is a stimulant with aphrodisiac and mild MAOI effects that primarily acts as an antagonist of α2 receptors. It is sometimes sold as prescription medicine in pure form for the treatment of xerostomia and sexual dysfunction. Yohimbine was explored as a remedy for type 2 diabetes in animal and human models carrying polymorphisms of the α2A-adrenergic receptor gene.
Yohimbine hydrochloride Applications:
1). Sexual dysfunction——–The NIH states that yohimbine hydrochloride is the standardized form of yohimbine that is available as a prescription medicine in the United States, and that it has been shown in human studies to be effective in the treatment of male erectile dysfunction. Yohimbine has been shown to be effective in the treatment of orgasmic dysfunction in men. Yohimbine has also been used to treat hypoactive sexual desire disorder (under active libido) in women.
2). Fat loss——–Yohimbine has shown to increase lipolysis in multiple studies.Administered prior to exercise, it boosts lipolysis and serum FFA levels both during and following exercise; blockade of adipocyte alpha-2 adrenoreceptors makes at least a modest contribution to this pro-lipolytic activity. Pre-exercise yohimbine administration has the potential to down-regulate the lipoprotein lipase activity of visceral adipocytes, increase lipolysis in refractory gynoid fat depots, and improve the impaired lipolytic response to exercise in the elderly
Yohimbine hydrochloride Specifications:
| ANALYSIS | SPECIFICATION | RESULTS |
| Appearance | White fine powder | Complies |
| Odor | Characteristic | Complies |
| Assay (HPLC) On dry basis | Yohimbine HCL≥98.0% | 99. 3% |
| Sieve analysis | NLT 100% pass 80 mesh | Complies |
| Melting point | 285-290°C | 288.2ºC |
| Boiling point | 542.979°C at 760 mmHg | Complies |
| Flash point | 282.184°C | Complies |
| Vapour Pressur | 0mmHg at 25°C | Complies |
| Specific Rotation | +100º to +105º | +103.80º |
| Solubility | Slightly soluble in Water/Alcohol | Complies |
| Loss on Drying | ≤1% | 0.7% |
| Residue on Ignition | ≤1% | 0.87% |
| Heavy Metal | <15ppm | <10ppm |
| As | <2.0ppm | <1ppm |
| Pb | <1.0ppm | <0.4ppm |
| Cd | <1.0ppm | 0ppm |
| Hg | <0.1ppm | 0ppm |
| Residual Solvents | Eur.Pharm. | Complies |
| Microbiology | ||
| Total Plate Count | <1000cfu/g | Complies |
| Yeast & Moulds | <100cfu/g | Complies |
| E.Coli | Negative | Complies |
| Salmonella | Negative | Complies |
| S.aureus | Negative | Complies |
Safety Concerns:
Patients sensitive to rauwolfia alkaloids such as deserpidine, rauwolfia serpentina, or reserpine may also be sensitive to yohimbine.
Yohimbine readily penetrates the (CNS) and produces a complex pattern of responses in lower doses than those required to produce peripheral alpha-adrenergic blockade. These include, anti-diuresis, a general picture of central excitation including elevation of blood pressure and heart rate, increased motor activity, nervousness, irritability and tremor. Sweating, nausea and vomiting are common after parenteral administration of the drug. Also, dizziness, headache skin flushing reported when used orally.
Generally, this drug is not proposed for use in females and certainly must not be used during pregnancy. Neither is this drug proposed for use in pediatric, geriatric or cardio-renal patients with gastric or duodenal ulcer history. Nor should it be used in conjunction with mood- modifying drugs such as antidepressants, or in psychiatric patients in general.
Renal diseases and patient’s sensitive to the drug. In view of the limited and inadequate information at hand, no precise tabulation can be offered of additional contraindications.
It is important that your doctor check your progress at regular visits to make sure that this medicine is working properly.
Use yohimbine exactly as directed by your doctor. Do not use more of it and do not use it more often than ordered. If too much is used, the risk of side effects such as fast heartbeat and high blood pressure is increased.
Dosage Information:
The dose of this medicine will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
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